From: James Kaufman <jkaufman**At_Symbol_Here**LABSAFETYINSTITUTE.ORG>
Subject: Re: [DCHAS-L] Best Practices Question
Date: Fri, 13 Aug 2021 11:15:40 -0400
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Message-ID: CAHk9oEQuy+Wjj5uxNeuOfhVzAgeuBQvTXh3Rg_cyfW6pxPEM1w**At_Symbol_Here**mail.gmail.com
In-Reply-To


Thanks Jack ... I will share this with the inquirer. He may be in touch.

Regards ... Jim

PS. LSI now has virtual lab inspections, safety program evaluations, document reviews, plus courses and seminars ... all virtual

James A. Kaufman, PhD

Founder/President Emeritus


The Laboratory Safety Institute (LSI)

A Nonprofit Educational Organization for Safety in Science, Industry, and Education

192 Worcester Street, Natick, MA 01760-2252

(O) 508-647-1900 (F) 508-647-0062 (C) 508-574-6264 Skype: labsafe; 508-401-7406

jim**At_Symbol_Here**labsafety.org www.labsafety.org Teach, Learn, and Practice Science Safely






On Fri, Aug 13, 2021 at 11:09 AM Jack Brown <orgchem1954**At_Symbol_Here**gmail.com> wrote:
Hello James;
In that case in industry we break it down by activities:
1. Setup
a. weighting out the substrate
b. weighting out the catalyst (this is typically one of the most riskiest activities (especially associated with palladium or platinum on carbon) also remember anything that touches the catalyst has a fire risk associated with
it.
c. charging the catalyst into reactor (need to ensure that reactor is empty and purged with nitrogen)
d. charging solvent and substrate (again ensure that reactor is purged with nitrogen)
2. Reaction
a. pressurization of reactor (ensuring that the reactor is not over pressurized)
b. if there is a additional charge of catalyst (charge of catalyst is very dangerous and due to the presence of active catalyst and solvent and hydrogen)
c. sampling (reaction mixture is flammable and potential pyrophoric)
d. depressurization (venting of hydrogen, hazards associated with venting hydrogen)
3. Workup
a. Filtering the catalyst off (extremely hazardous due to the solvent and active catalyst)
b. deposing of the spent catalyst, another extremely hazardous task and one that is not an area of focus.
We can discuss further if you need more detail
Thanks
Jack


On Wed, Aug 11, 2021 at 8:48 PM James Kaufman <jkaufman**At_Symbol_Here**labsafetyinstitute.org> wrote:
Lab scale.

James A. Kaufman, Ph.D.
Founder, LSI
508-574-6264

On Wed, Aug 11, 2021, 5:48 PM Jack Brown <orgchem1954**At_Symbol_Here**gmail.com> wrote:
Hello James;
There are several groups that might be interesting for you to talk to. However, are you interested in only lab scale hydrogenations or larger scales? And as far as methanol filtrations or is this focused on filtration after the hydrogenation is completed?
Thanks
Jack D. Brow

On Wed, Aug 11, 2021 at 2:45 PM James Kaufman <jim**At_Symbol_Here**labsafety.org> wrote:
A colleague asked me to gather your thoughts about the following inquiry.

Do you know, or do you know of someone/group I could talk to concerning industry best practices about hydrogenation/open access hydrogenation/methanol/filtration, etc.? We would like to see if there are some practices out there that we haven't considered.

Regards ... Jim

James A. Kaufman, PhD

Founder/President Emeritus


The Laboratory Safety Institute (LSI)

A Nonprofit Educational Organization for Safety in Science, Industry, and Education

192 Worcester Street, Natick, MA 01760-2252

(O) 508-647-1900 (F) 508-647-0062 (C) 508-574-6264 Skype: labsafe; 508-401-7406

jim**At_Symbol_Here**labsafety.org www.labsafety.org Teach, Learn, and Practice Science Safely





--- For more information about the DCHAS-L e-mail list, contact the Divisional membership chair at membership**At_Symbol_Here**dchas.org Follow us on Twitter **At_Symbol_Here**acsdchas
--- For more information about the DCHAS-L e-mail list, contact the Divisional membership chair at membership**At_Symbol_Here**dchas.org Follow us on Twitter **At_Symbol_Here**acsdchas
--- For more information about the DCHAS-L e-mail list, contact the Divisional membership chair at membership**At_Symbol_Here**dchas.org Follow us on Twitter **At_Symbol_Here**acsdchas
--- For more information about the DCHAS-L e-mail list, contact the Divisional membership chair at membership**At_Symbol_Here**dchas.org Follow us on Twitter **At_Symbol_Here**acsdchas
--- For more information about the DCHAS-L e-mail list, contact the Divisional membership chair at membership**At_Symbol_Here**dchas.org Follow us on Twitter **At_Symbol_Here**acsdchas

Previous post   |  Top of Page   |   Next post



The content of this page reflects the personal opinion(s) of the author(s) only, not the American Chemical Society, ILPI, Safety Emporium, or any other party. Use of any information on this page is at the reader's own risk. Unauthorized reproduction of these materials is prohibited. Send questions/comments about the archive to secretary@dchas.org.
The maintenance and hosting of the DCHAS-L archive is provided through the generous support of Safety Emporium.