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Ketone

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Ketosis

Definition

• Ketosis is the presence of excess ketones in the body and may also appear as the term dietary ketosis (more below). Ketosis is generally not life-threatening.
• Ketoacidosis is a severe form of ketosis. The term may appear in reference to diabetes, as diabetic ketoacidosis or the consumption of too much alcohol as alcoholic ketoacidosis. Such cases can have serious health effects, particularly if the ketoacidosis goes untreated for long periods of time.

Consult our more extensive discussion of ketones for details on their chemical structure, naming and more.

Additional Info

Ketones are a normal byproduct of fat metabolism (the breaking down of fat into energy). Normally, your body is efficient at removing these, but when certain enzymes are absent or damaged, the concentration of ketones in the body can build up. Ketosis indicates a blood ketone concentration between 0.3 and 7.0 mmol/L and ketoacidosis reflects levels of 7.0 mmol/L or higher. Ketoacidosis gets its name because high blood ketone levels lower the pH of your blood to 7.3 or lower. Severe and/or prolonged cases of ketoacidosis can lead to coma and death if not properly treated. Certain individuals are predisposed towards ketosis or ketoacidosis. For example, those with diabetes have insufficient insulin levels and their bodies have difficulty processing glucose (sugar). If a diabetic does not alter his or her diet to reduce sugar intake and/or take additional insulin, their body will break down fat, leading to a rise in ketone levels. The complexities of diabetes and ketoacidosis are beyond the scope of this discussion; see the links under Further Reading for more information. Popular low-carbohydrate diets (such as Atkins) encourage the breakdown of fat and can induce so-called dietary ketosis, but this condition is generally not harmful provided the individual is otherwise healthy and stays well-hydrated. Ketones can be excreted through the urine and those that are volatile (such as acetone) can be expelled through the lungs. Diabetics can be mistaken for being drunk by the odor on their breath, and acetone being expelled through the lungs can give a false positive result on early model breathalyzers. However, don't expect to escape a ticket as driving while impaired (due to low blood sugar) is still a traffic offense whether you are drunk or not.

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MSDS Relevance

Certain chemicals can directly or indirectly cause the formation of excess ketones in the body. Know the dangers of the chemicals you are working with by carefully reading the labels and MSDS sheets. Follow appropriate precautions when working with ketones and aldehydes.

Further Reading

• Diabetic ketoacidosis and alcoholic ketoacidosis in the Merck Manual.
• Diabetic ketoacidosis at eMedicine.com is geared towards health professionals.
• Ketosis at WrongDiagnosis.com.
• The American Diabetes Association.

See also: alcohol, chemical formula, ketone.

Additional definitions from Google and OneLook.

Disclaimer: The information contained herein is believed to be true and accurate, however ILPI makes no guarantees concerning the veracity of any statement. Use of any information on this page is at the reader's own risk. ILPI strongly encourages the reader to consult the appropriate local, state and federal agencies concerning the matters discussed herein.