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- A clastogen is a substance that cause breaks in chromosomes that result in the gain, loss, or rearrangements of chromosomal segments. Clastogens can also cause sister chromatid exchanges, the interchanges and reunions that occur during the processes of mitosis or meiosis (DNA replication).
Clastogens break and/or damage your DNA. If the cell dies, then there may be no further health effect. But if the altered/damaged cell's DNA functions and is replicated (reproduced; passed on), this may lead to mutagenesis or carcinogenesis. While all gene mutations generally involve clastogenesis, the reverse is not always true - not all clastogens produce gene mutations.
Examples of known human clastogens include certain anti-cancer drugs, benzene, ethylene oxide and inorganic arsenic. X-ray and ultraviolet radiation can also be considered clastogens.
- "Introduction to the Cellular and Molecular Biology of Cancer", Paperback, 552 pages, 2005. Estimated price: $101.00. Info and/or order.
- "DNA Repair And Mutagenesis", Hardcover, 1,118 pages, 2005. Estimated price: $79.56. Info and/or order.
- "The Principles of Clinical Cytogenetics", Hardcover, 616 pages, 2004. Estimated price: $107.62. Info and/or order.
- "Biology of Cancer", Paperback, 850 pages, 2006. Estimated price: $99.54. Info and/or order.
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