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Substances that are reasonably anticipated to be human carcinogens meet any of the following descriptions:
The original 1986 and 1994 edition of OSHA's Hazardous Communication standard 1910.1200 (HCS 1994) relied on these three agencies for determining whether a chemical was a known or potential (reasonably anticipated to be a) human carcinogen:
Note: The "Registry of Toxic Effects of Chemical Substances" published by the National Institute for Occupational Safety and Health (NIOSH) indicated whether a chemical had been found by NTP or IARC to be a potential carcinogen.
The current edition of the HazCom Standard (HCS 2012) backs off somewhat on that absolute determination schema and expands the scope of the carcinogenicity determination. While a carcinogenic hazard classification must given to the material if it is listed under 29 CFR part 1910, subpart Z per Section A.6.4.2 and the SDS author has the option of relying on the IARC and NTP data to make the classification, the author is not required to automatically classify substances as carcinogens based solely on NTP or IARC data.
Instead, the current edition uses a broad evidence-based approach which is laid out in considerable detail in Section A.6 of Appendix A to HCS 2012. Under this new schema, substances are allocated into two categories based on the strength of the scientific evidence for carcinogenicity and then additional considerations based on human cancer potential. In theory, this cuts both ways, for example, a manufacturer could argue that because the human risk is low, an IARC-listed substance might not require a carcinogenic hazard classification. On the other hand, the new approach also gives the manufacturer the ability to state that their product should be considered carcinogenic in order to fully disclose a potential hazard they have become aware of (perhaps to shield them from legal liability, for example).
According to NIOSH's Publication No. 2010-145 (May 2010), past estimates that about 4% of cancer deaths in the U.S. are caused by occupational exposures have underestimated the actual rate. For example, exposures to carcinogens in the workplace may not result in cancer until 15-40 years later.
Use extreme caution when working with carcinogenic (or potentially carcinogenic) materials in the workplace. Be sure to use all proper personal protective equipment (PPE) and to minimize your exposure. Find alternative procedures or materials if possible; while these may cost a little more in up-front costs, the long term savings in disposal costs, litigation etc. usually more than make up for such an expense. Proper engineering controls and adminstrative controls are definitely required when working with carcinogens or potential carcinogens!
See also: carcinoma, clastogen, mutagen, National Toxicology Program (NTP), teratogen.
Additional definitions from Google and OneLook.
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