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Mutagen

Definition

• A mutagen is a substance or agent that causes an increase in the rate of change in genes (subsections of the DNA of the body's cells). These mutations (changes) can be passed along as the cell reproduces, sometimes leading to defective cells or cancer.

  Examples of mutagens include certain biological and chemical agents as well exposure to ultraviolet light or ionizing radiation.

• Mutagenesis is the formation of mutations.

Additional Info

There are many types of mutations, some of which are harmful and others which have little or no effect on the body's function. See the DNA and Mutations a clear, multi-page resource at the U of California at Berkeley.

Mutagens can be identified using the Ames test and other biochemical testing methods.

Do not confuse a mutagen with a carcinogen (a substance that causes cancer). Mutagens may cause cancer, but not always.

Do not confuse a mutagen with a teratogen (a substance that causes change or harm to a fetus or embryo).

Books Available

• "Chemical Consequences: Environmental Mutagens, Scientist Activism, and the Rise of Genetic Toxicology", Paperback, 197 pages, 2004. Estimated price $23.95. Info and/or order.

MSDS Relevance Avoid working with mutagens whenever possible. If you must work with a mutagen be sure to wear personal protective equipment (PPE) and utilize workplace controls such as a fume hoods to minimize your exposure. Further Reading Guidance On A Strategy For Testing Of Chemicals For Mutagenicity by the Committee of Mutagenicity. Ethidium Bromide Fact Sheet - this material is one of the most potent mutagens commonly used in laboratories. The Environmental Mutagen Society studies mutagenesis and its applications to genetic toxicology. Mutation, Mutagens, and DNA Repair at Kansas State University. See also: carcinogen, clastogen, cytotoxin, teratogen. Additional definitions from Google and OneLook.

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Disclaimer: The information contained herein is believed to be true and accurate, however ILPI makes no guarantees concerning the veracity of any statement. Use of any information on this page is at the reader's own risk. ILPI strongly encourages the reader to consult the appropriate local, state and federal agencies concerning the matters discussed herein.