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|LDLo, Lowest Lethal Dose|
LDLo is closely related to the LD50 value which is the dosage which kills half of the test animals under controlled conditions.
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Both LD50 and LDLo values state the animal used in the test. This is important because animal toxicity studies do not necessarily extrapolate (extend) to humans. For example, dioxins (of Love Canal, Times Beach, Sveso and Agent Orange fame) are highly toxic to guinea pigs and ducklings at extremely low levels, but have never been unambiguously linked to a single human death even at very high levels of acute (short term) exposure; note, however they are listed by IARC as "known human carcinogens". However, it is best to err on the safe side when evaluating animal toxicity studies and assume that most chemicals that are toxic to animals are toxic to humans.
Pay close attention to the permissible exposure level (PEL) instead. This is a more realistic determination of the maximum safe exposure to a material and is usually based on the known effects of the chemical on humans rather than laboratory animals.
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