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Risk Phrases (R-phrases)

Definition

The European Union (EU) requires that risk phrases (R-phrases) appear on each label and safety data sheet for hazardous chemicals. R-phrases consist of the letter R followed by a number. The precise meaning of each of these appears in the table below.

Labels will also have symbols or pictograms (see CHIP), but the R-phrase specifies the particular danger(s). For example, sodium metal may have a large F and flame icon on the label, but the particular risk is denoted by R14/15 and R34 which correspond to "Reacts violently with water liberating highly flammable gases" and "causes burns".

Safety phrases (S-phrases) for handling precautions are also part of the same requirements.

Additional Info

Both risk and safety phrases are being phased out in favor of Hazard Statements and Precautionary Statements under the EU's implementation of the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) per EU Regulation (EC) 1272/2008 (6.6 MB PDF file).

More than one R-phrase may appear on an MSDS. These are usually presented in combination, such as R36/37/38. In the first table below, single phrases are given, and in the second table, combinations are given. In general, no more than four R-phrases should be sufficient to adequately communicate the risks of a particular material. The R phrases selected should be those applicable to the substance(s) present in the concentration which gives rise to the most severe classification (for example, T+ versus T).

Conversions from R-statements to H-statements can be found starting on page 1352 of EU Regulation (EC) 1272/2008.

Single Risk Phrases
R1	Explosive when dry.
R2	Risk of explosion by shock, friction, fire or other sources of ignition.
R3	Extreme risk of explosion by shock, friction, fire or other sources of ignition.
R4	Forms very sensitive explosive metallic compounds.
R5	Heating may cause an explosion.
R6	Explosive with or without contact with air.
R7	May cause fire.
R8	Contact with combustible material may cause fire.
R9	Explosive when mixed with combustible material.
R10	Flammable.
R11	Highly flammable.
R12	Extremely flammable.
R13	Extremely flammable liquified gas. This code is no longer in use.
R14	Reacts violently with water.
R15	Contact with water liberates highly flammable gases.
R16	Explosive when mixed with oxidizing substances.
R17	Spontaneously flammable in air.
R18	In use, may form flammable/explosive vapour-air mixture.
R19	May form explosive peroxides.
R20	Harmful by inhalation.
R21	Harmful in contact with skin.
R22	Harmful if swallowed.
R23	Toxic by inhalation.
R24	Toxic in contact with skin.
R25	Toxic if swallowed.
R26	Very toxic by inhalation.
R27	Very toxic in contact with skin.
R28	Very toxic if swallowed.
R29	Contact with water liberates toxic gases.
R30	Can become highly flammable in use.
R31	Contact with acids liberates toxic gas.
R32	Contact with acids liberates Very toxic gas.
R33	Danger of cumulative effects.
R34	Causes burns.
R35	Causes severe burns.
R36	Irritating to eyes.
R37	Irritating to respiratory system.
R38	Irritating to skin.
R39	Danger of very serious irreversible effects.
R40	Possible risks of irreversible effects.
R41	Risk of serious damage to eyes.
R42	May cause sensitization by inhalation.
R43	May cause sensitization by skin contact.
R44	Risk of explosion if heated under confinement.
R45	May cause cancer.
R46	May cause heritable genetic damage.
R47	May cause birth defects.
R48	Danger of serious damage to health by prolonged exposure.
R49	May cause cancer by inhalation.
R50	Very toxic to aquatic organisms.
R51	Toxic to aquatic organisms.
R52	Harmful to aquatic organisms.
R53	May cause long-term adverse effects in the aquatic environment.
R54	Toxic to flora.
R55	Toxic to fauna.
R56	Toxic to soil organisms.
R57	Toxic to bees.
R58	May cause long-term adverse effects in the environment.
R59	Dangerous for the ozone layer.
R60	May impair fertility.
R61	May cause harm to the unborn child.
R62	Possible risk of impaired fertility.
R63	Possible risk of harm to the unborn child.
R64	May cause harm to breastfed babies.

Multiple Risk Phrases
R14/15	Reacts violently with water liberating highly flammable gases.
R15/29	Contact with water liberates toxic, highly flammable gas.
R20/21	Harmful by inhalation and in contact with skin.
R20/22	Harmful by inhalation and if swallowed.
R20/21/22	Harmful by inhalation, in contact with skin and if swallowed.
R21/22	Harmful in contact with skin and if swallowed.
R23/24	Toxic by inhalation and in contact with skin.
R23/25	Toxic by inhalation and if swallowed.
R23/24/25	Toxic by inhalation, in contact with skin and if swallowed.
R24/25	Toxic in contact with skin and if swallowed.
R26/27	Very toxic by inhalation and in contact with skin.
R26/28	Very toxic by inhalation and if swallowed.
R26/27/28	Very toxic by inhalation, in contact with skin and if swallowed.
R27/28	Very toxic in contact with skin and if swallowed.
R36/37	Irritating to eyes and respiratory system.
R36/38	Irritating to eyes and skin.
R36/37/38	Irritating to eyes, respiratory system and skin.
R37/38	Irritating to respiratory system and skin.
R39/23	Toxic: danger of very serious irreversible effects through inhalation.
R39/24	Toxic: danger of very serious irreversible effects in contact with skin.
R39/25	Toxic: danger of very serious irreversible effects if swallowed.
R39/23/24	Toxic: danger of very serious irreversible effects through inhalation and in contact with skin.
R39/23/25	Toxic: danger of very serious irreversible effects through inhalation and if swallowed.
R39/24/25	Toxic: danger of very serious irreversible effects in contact with skin and if swallowed.
R39/23/24/25	Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed.
R39/26	Very toxic: danger of very serious irreversible effects through inhalation.
R39/27	Very toxic: danger of very serious irreversible effects in contact with skin.
R39/28	Very toxic: danger of very serious irreversible effects if swallowed.
R39/26/27	Very toxic: danger of very serious irreversible effects through inhalation and in contact with skin.
R39/26/28	Very toxic: danger of very serious irreversible effects through inhalation and if swallowed.
R39/27/28	Very toxic: danger of very serious irreversible effects in contact with skin and if swallowed.
R39/26/27/28	Very toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed.
R40/20	Harmful: possible risk of irreversible effects through inhalation.
R40/21	Harmful: possible risk of irreversible effects in contact with skin.
R40/22	Harmful: possible risk of irreversible effects if swallowed.
R40/20/21	Harmful: possible risk of irreversible effects through inhalation and in contact with skin.
R40/20/22	Harmful: possible risk of irreversible effects through inhalation and if swallowed.
R40/21/22	Harmful: possible risk of irreversible effects in contact with skin and if swallowed.
R40/20/21/22	Harmful: possible risk of irreversible effects through inhalation, in contact with skin and if swallowed.
R42/43	May cause sensitization by inhalation and skin contact.
R48/20	Harmful: danger of serious damage to health by prolonged exposure through inhalation.
R48/21	Harmful: danger of serious damage to health by prolonged exposure in contact with skin.
R48/22	Harmful: danger of serious damage to health by prolonged exposure if swallowed.
R48/20/21	Harmful: danger of serious damage to health by prolonged exposure through inhalation and in contact with skin.
R48/20/22	Harmful: danger of serious damage to health by prolonged exposure through inhalation and if swallowed.
R48/21/22	Harmful: danger of serious damage to health by prolonged exposure in contact with skin and if swallowed.
R48/20/21/22	Harmful: danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed.
R48/23	Toxic: danger of serious damage to health by prolonged exposure through inhalation.
R48/24	Toxic: danger of serious damage to health by prolonged exposure in contact with skin.
R48/25	Toxic: danger of serious damage to health by prolonged exposure if swallowed.
R48/23/24	Toxic: danger of serious damage to health by prolonged exposure through inhalation and in contact with skin.
R48/23/25	Toxic: danger of serious damage to health by prolonged exposure through inhalation and if swallowed.
R48/24/25	Toxic: danger of serious damage to health by prolonged exposure in contact with skin and if swallowed.
R48/23/24/25	Toxic: danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed.
R50/53	Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R51/53	Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R52/53	Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

MSDS Relevance Risk phrases are not required on labels or MSDS's by U.S. OSHA, however, they are required in the European Community. Therefore, you may see these R phrases on your sheets, especially as manufacturers start following internationally-accepted formats such as the ANSI system. Or you may start seeing H-statements instead of risk phrases as the GHS is phased in. Remember that risk phrases indicate only the risk of a material, not the safety precautions that you need to follow. For safety information see the safety phrases entry. Further Reading The Basics of Chemical Safety at the International Occupational Safety and Health Information Centre (CIS) discusses R- and S-phrases, and includes a list of chemicals. A R- and S-phrases language conversion tool in 23 languages at SchoolScout24. Council Directive 2006/102/EC (PDF file) contains R- and S-phrases as well as other hazard terms in 23 languages. The Provisions for Classifying Dangerous Preparations (see Schedule 3) discusses how risks and risk phrases are quantified.

Gas cylinder tags and all kind of workplace accessories are available at Safety Emporium

See also: ANSI, CHIP, EINECS, Hazard Statements, safety phrases and the International Section of the MSDS FAQ.

Additional definitions from Google and OneLook.

Disclaimer: The information contained herein is believed to be true and accurate, however ILPI makes no guarantees concerning the veracity of any statement. Use of any information on this page is at the reader's own risk. ILPI strongly encourages the reader to consult the appropriate local, state and federal agencies concerning the matters discussed herein.